A strike against indolent neuroblastoma

A Nuclear Strike against Listeria— The Evolving Life of LXR

LXRs are members of the nuclear receptor superfamily and function as master regulators of cholesterol metabolism. In the macrophage, they control cholesterol efflux and inhibit the transcription factor NF-kappaB-mediated proinflammatory responses. In this issue of Cell, discover surprising, protective functions for LXRalpha in innate immunity.

Platelet activation: yet another strike against routine TRANSFUSION.

In the past, anaemia in patients with established coronary artery disease, especially acute anaemia as a result of bleeding, has been treated with a relatively liberal use of allogenic red blood cell (RBC) transfusions. RBC transfusions are believed to increase oxygen delivery by increasing haemoglobin concentration. Therefore, transfusion would seem to be a logical approach, as anaemia is asso...

To strike or not to strike.

False discovery rates of protein identifications: a strike against the two-peptide rule.

Most proteomics studies attempt to maximize the number of peptide identifications and subsequently infer proteins containing two or more peptides as reliable protein identifications. In this study, we evaluate the effect of this "two-peptide" rule on protein identifications, using multiple search tools and data sets. Contrary to the intuition, the "two-peptide" rule reduces the number of protei...

Spectral probabilities and generating functions of tandem mass spectra: a strike against decoy databases.

A key problem in computational proteomics is distinguishing between correct and false peptide identifications. We argue that evaluating the error rates of peptide identifications is not unlike computing generating functions in combinatorics. We show that the generating functions and their derivatives ( spectral energy and spectral probability) represent new features of tandem mass spectra that,...